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ea0010dp4 | Diabetes, metabolism and cardiovascular | SFE2005

Familial diabetes in Asian families; remember MODY

Porter J , Rangasami J , Ellard S , Gloyn A , Edwards J , Anderson J , Plunkett M , Shaw N , Frayling T , Hattersley A , Barrett T

Type 2 diabetes (T2DM) has emerged in youth, disproportionately affecting ethnic minorities. Maturity Onset Diabetes of the Young (MODY) has been reported in exclusively white UK children. We report the first UK Asian children with MODY, highlighting differences from T2DM.Child 1 is a slim (BMI SDS−0.14) female of Indian descent without acanthosis nigricans (AN). She presented aged 12 years with polydipsia and polyuria (HbA1c 8.6%). Hypoglycaemia w...

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ea0009p137 | Steroids | BES2005

Development of a cortisol binding capacity assay for use in the newborn

Smith J , Armstrong L , Hoftijzer D , Midgley P , Mallam B , Armstrong J , Yorke J , Edwards A , Wilson C

Background: The action of a steroid in any physiological process is dependent on the bioavailable (free) fraction. Direct measurements of free cortisol are expensive, labour intensive and require a significant volume of plasma and as a consequence are not feasible in the neonate. One alternative is to calculate free cortisol from the Cortisol Binding Capacity (CBC) and the total plasma cortisol. The aim of the present study was to develop an assay for the measurement of CBC in...

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Endocrine Abstracts

Familial diabetes in Asian families; remember MODY

Development of a cortisol binding capacity assay for use in the newborn

BiosciAbstracts